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From 1957 to 2020’s and how we treat weight loss What weight loss pill has proven to have the most success? The most effective weight loss pill / drug available currently (2019) is Phentermine-Topiramate extended release (Qsymia). Phentermine-Topiramate combines an adrenergic agonist (Sympathomimetics) with a neuro stabilizer. Better candidates for this type of weight loss…